Article
High-throughput single nucleotide polymorphism genotyping using nanofluidic Dynamic Arrays.
BMC genomics - 28 Nov 2009
Wang Jun, Lin Min, Crenshaw Andrew, Hutchinson Amy, Hicks Belynda, Yeager Meredith, Berndt Sonja, Huang Wen-Yi, Hayes Richard B, Chanock Stephen J, Jones Robert C, Ramakrishnan Ramesh
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms (SNPs) have emerged as the genetic marker of choice for mapping disease loci and candidate gene association studies, because of their high density and relatively even distribution in the human genomes. There is a need for systems allowing medium multiplexing (ten to hundreds of SNPs) with high throughput, which can efficiently and cost-effectively generate genotypes for...
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