Article
p38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage.
Scientific reports - 24 Jul 2017
de Sousa Mirta Mittelstedt Leal, Bjørås Karine Øian, Hanssen-Bauer Audun, Solvang-Garten Karin, Otterlei Marit
Abstract excerpt
XRCC1 is a scaffold protein involved in base excision repair and single strand break repair. It is a phosphoprotein that contains more than 45 phosphorylation sites, however only a few of these have been characterized and connected to specific kinases and functions. Mitogen activated protein kinases (MAPK) are mediators of cellular stress responses, and here we demonstrate that p38 MAPK signaling is involved in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.