Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase.

Molecular and cellular biology - 1 Mar 2015

Ray Chaudhuri Arnab, Ahuja Akshay Kumar, Herrador Raquel, Lopes Massimo

Abstract excerpt

Poly(ADP-ribosyl)ation (PAR) has been implicated in various aspects of the cellular response to DNA damage and genome stability. Although 17 human poly(ADP-ribose) polymerase (PARP) genes have been identified, a single poly(ADP-ribosyl) glycohydrolase (PARG) mediates PAR degradation. Here we investigated the role of PARG in the replication of human chromosomes. We show that PARG depletion affects cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to DNA, Single-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycoside Hydrolases

Share to GTPase-Activating Proteins

Share to Microscopy, Confocal

Share to Rad51 Recombinase

Share to S Phase

Share to Tumor Suppressor p53-Binding Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 25535335
DOI: 10.1128/MCB.01077-14
PMCID: PMC4323491

Genes

PARG
ATM
ATR
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase.PMID 25535335Read ↗

DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase InhibitorsSemantic proximity Read ↗

PARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancerSemantic proximity Read ↗

PARG inhibition induces replication catastrophe in ovarian cancer cells with down-regulated DNA replication genesSemantic proximity Read ↗

PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathwaysSemantic proximity Read ↗

PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkersSemantic proximity Read ↗

The oncoprotein DEK affects the outcome of PARP1/2 inhibition during replication stressSemantic proximity Read ↗

Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer modelsSemantic proximity Read ↗

Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human diseaseSemantic proximity Read ↗

Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation.Semantic proximity Read ↗

Poly(ADP‐ribose) and carcinogenesisSemantic proximity Read ↗

CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancerSemantic proximity Read ↗

RB loss sensitizes cells to replication-associated DNA damage after PARP inhibition by trappingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.