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Article

Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns.

Blood - 15 Nov 2012

Schuh Anna, Becq Jennifer, Humphray Sean, Alexa Adrian, Burns Adam, Clifford Ruth, Feller Stephan M, Grocock Russell, Henderson Shirley, Khrebtukova Irina, Kingsbury Zoya, Luo Shujun, McBride David, Murray Lisa, Menju Toshi, Timbs Adele, Ross Mark, Taylor Jenny, Bentley David

Abstract excerpt

Chronic lymphocytic leukemia is characterized by relapse after treatment and chemotherapy resistance. Similarly, in other malignancies leukemia cells accumulate mutations during growth, forming heterogeneous cell populations that are subject to Darwinian selection and may respond differentially to treatment. There is therefore a clinical need to monitor changes in the subclonal composition of cancers during...

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Share to Cell Transformation, Neoplastic
Share to Clone Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA, Neoplasm

Share to Evolution, Molecular

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Neoplasm Proteins

Share to Selection, Genetic

Source

Identifiers

PMID: 22915640
DOI: 10.1182/blood-2012-05-433540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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