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Article

CotH3 mediates fungal invasion of host cells during mucormycosis

19 Dec 2013

Abstract excerpt

Angioinvasion is a hallmark of mucormycosis. Previously, we identified endothelial cell glucose-regulated protein 78 (GRP78) as a receptor for Mucorales that mediates host cell invasion. Here we determined that spore coat protein homologs (CotH) of Mucorales act as fungal ligands for GRP78. CotH proteins were widely present in Mucorales and absent from noninvasive pathogens. Heterologous expression of CotH3 and...

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PMID: 24355926
DOI: 10.1172/jci71349

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