Article

A novel resistance pathway for calcineurin inhibitors in the human pathogenic Mucorales <i>Mucor circinelloides</i>

2019-11-07

Abstract excerpt

Mucormycosis is an emerging lethal fungal infection in immunocompromised patients. Mucor circinelloides is a causal agent of mucormycosis and serves as a model system to understand genetics in Mucorales. Calcineurin is a conserved virulence factor in many pathogenic fungi and calcineurin inhibition or deletion of the calcineurin regulatory subunit (CnbR) in Mucor results in a shift from hyphal to yeast growth. W...

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Literature Corpus work: 9e70f7ed-f719-5b9b-b2d7-823e8678b6b8
DOI: 10.1101/834143

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