Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides.

mBio - 28 Jan 2020

Vellanki Sandeep, Billmyre R Blake, Lorenzen Alejandra, Campbell Micaela, Turner Broderick, Huh Eun Young, Heitman Joseph, Lee Soo Chan

Abstract excerpt

Mucormycosis is an emerging lethal fungal infection in immunocompromised patients. Mucor circinelloides is a causal agent of mucormycosis and serves as a model system to understand genetics in Mucorales. Calcineurin is a conserved virulence factor in many pathogenic fungi, and calcineurin inhibition or deletion of the calcineurin regulatory subunit (CnbR) in Mucor results in a shift from hyphal to yeast growth....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Calcineurin Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Fungal

Share to Fungal Proteins

Share to Gene Expression Regulation, Fungal

Share to Host-Pathogen Interactions

Share to Virulence

Share to Virulence Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 31992620
DOI: 10.1128/mBio.02949-19
PMCID: PMC6989107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides.PMID 31992620Read ↗

A novel resistance pathway for calcineurin inhibitors in the human pathogenic Mucorales <i>Mucor circinelloides</i>Semantic proximity Read ↗

Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides.Semantic proximity Read ↗

Recent Advances and Future Directions in the Understanding of MucormycosisSemantic proximity Read ↗

The amino acid permease Byc1 is involved in calcineurin-dependent thermos-tolerance in <i>Cryptococcus neoformans</i>Semantic proximity Read ↗

Molecular mechanisms that govern infection and antifungal resistance in MucoralesSemantic proximity Read ↗

Calcineurin-dependent contributions to fitness in the opportunistic pathogen Candida glabrataSemantic proximity Read ↗

Duplication and overexpression of the genes encoding a beta 1,3-glucan synthase confer the intrinsic resistance to echinocandin in <i>Mucor circinelloides</i>Semantic proximity Read ↗

Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factorsSemantic proximity Read ↗

The calcineurin pathway regulates extreme thermotolerance, cell membrane and wall integrity, antifungal resistance, and virulence in Candida aurisSemantic proximity Read ↗

Convergent Evolution of Calcineurin Pathway Roles in Thermotolerance and Virulence in<i>Candida glabrata</i>Semantic proximity Read ↗

Calcineurin Controls Hyphal Growth, Virulence, and Drug Tolerance of Candida tropicalisSemantic proximity Read ↗

Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.