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Article

Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel.

DNA repair - 1 Jan 2014

Gao Rui, Das Benu Brata, Chatterjee Raghunath, Abaan Ogan D, Agama Keli, Matuo Renata, Vinson Charles, Meltzer Paul S, Pommier Yves

Abstract excerpt

Tyrosyl-DNA-phosphodiesterase 1 (TDP1) repairs 3'-blocking DNA lesions by catalytically hydrolyzing the tyrosyl-DNA-phosphodiester bond of trapped topoisomerase I (Top1) cleavage complexes (Top1cc). It also removes 3'-blocking residues derived from oxidative damage or incorporation of chain terminating anticancer and antiviral nucleosides. Thus, TDP1 is regarded as a determinant of resistance to Top1 inhibitors...

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Source

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Identifiers

PMID: 24355542
DOI: 10.1016/j.dnarep.2013.09.001
PMCID: PMC3919147

Genes

TDP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel.PMID 24355542Read ↗

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