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Article

scyllo-Inositol promotes robust mutant Huntingtin protein degradation.

The Journal of biological chemistry - 7 Feb 2014

Lai Aaron Y, Lan Cynthia P, Hasan Salwa, Brown Mary E, McLaurin Joanne

Abstract excerpt

Huntington disease is characterized by neuronal aggregates and inclusions containing polyglutamine-expanded huntingtin protein and peptide fragments (polyQ-Htt). We have used an established cell-based assay employing a PC12 cell line overexpressing truncated exon 1 of Htt with a 103-residue polyQ expansion that yields polyQ-Htt aggregates to investigate the fate of polyQ-Htt-drug complexes. scyllo-Inositol is an...

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Identifiers

PMID: 24352657
DOI: 10.1074/jbc.M113.501635
PMCID: PMC3916565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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