Article
Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations.
Autophagy - 1 Jan 2000
Sarkar Sovan, Rubinsztein David C
Abstract excerpt
We recently showed that lithium induces autophagy via inositol monophosphatase (IMPase) inhibition, leading to free inositol depletion and reduced myo-inositol-1,4, 5-triphosphate (IP3) levels. This represents a novel way of regulating mammalian autophagy, independent of the mammalian target of rapamycin (mTOR). Induction of autophagy by lithium led to enhanced clearance of autophagy substrates, like mutant...
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