Article
Lithium induces autophagy by inhibiting inositol monophosphatase.
The Journal of cell biology - 26 Sept 2005
Sarkar Sovan, Floto R Andres, Berger Zdenek, Imarisio Sara, Cordenier Axelle, Pasco Matthieu, Cook Lynnette J, Rubinsztein David C
Abstract excerpt
Macroautophagy is a key pathway for the clearance of aggregate-prone cytosolic proteins. Currently, the only suitable pharmacologic strategy for up-regulating autophagy in mammalian cells is to use rapamycin, which inhibits the mammalian target of rapamycin (mTOR), a negative regulator of autophagy. Here we describe a novel mTOR-independent pathway that regulates autophagy. We show that lithium induces autophagy,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.