Article
Genetic ablation and chemical inhibition of IP3R1 reduce mutant huntingtin aggregation.
Biochemical and biophysical research communications - 9 Dec 2011
Bauer Peter O, Hudec Roman, Ozaki Shoichiro, Okuno Misako, Ebisui Etsuko, Mikoshiba Katsuhiko, Nukina Nobuyuki
Abstract excerpt
Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by an expansion of the polyglutamine (polyQ) stretch in huntingtin (htt). Previously, it has been shown that inhibition of the inositol 1,4,5-trisphosphate receptor type 1 (IP3R1) activity reduced aggregation of pathogenic polyQ proteins. Experimentally, this effect was achieved by modification of the intracellular IP3 levels or...
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