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Enterovirus particles expel capsid pentamers to enable genome release

8 Mar 2019

Abstract excerpt

Viruses from the genus Enterovirus are important human pathogens. Receptor binding or exposure to acidic pH in endosomes converts enterovirus particles to an activated state that is required for genome release. However, the mechanism of enterovirus uncoating is not well understood. Here, we use cryo-electron microscopy to visualize virions of human echovirus 18 in the process of genome release. We discover that...

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PMID: 30850609
DOI: 10.1038/s41467-019-09132-x

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