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Article

Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1

20 Jul 2020

Abstract excerpt

KREMEN1 (KRM1) has been identified as a functional receptor for Coxsackievirus A10 (CV-A10), a causative agent of hand-foot-and-mouth disease (HFMD), which poses a great threat to infants globally. However, the underlying mechanisms for the viral entry process are not well understood. Here we determined the atomic structures of different forms of CV-A10 viral particles and its complex with KRM1 in both neutral...

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PMID: 32690697
DOI: 10.1073/pnas.2005341117

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