Article
"Outlaw" mutations in quasispecies of SARS-CoV-2 inhibit replication.
Emerging microbes & infections - 1 Dec 2024
Colson Philippe, Fantini Jacques, Delerce Jeremy, Bader Wahiba, Levasseur Anthony, Pontarotti Pierre, Devaux Christian, Raoult Didier
Abstract excerpt
The evolution of SARS-CoV-2, the agent of COVID-19, has been remarkable for its high mutation potential, leading to the appearance of variants. Some mutations have never appeared in the published genomes, which represent consensus, or bona fide genomes. Here we tested the hypothesis that mutations that did not appear in consensus genomes were, in fact, as frequent as the mutations that appeared during the various...
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