Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.

Cancer research - 1 Feb 2014

Guillemette Shawna, Branagan Amy, Peng Min, Dhruva Aashana, Schärer Orlando D, Cantor Sharon B

Abstract excerpt

Nucleotide excision repair (NER) is critical for the repair of DNA lesions induced by UV radiation, but its contribution in replicating cells is less clear. Here, we show that dual incision by NER endonucleases, including XPF and XPG, promotes the S-phase accumulation of the BRCA1 and Fanconi anemia-associated DNA helicase FANCJ to sites of UV-induced damage. FANCJ promotes replication protein A phosphorylation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic-Leucine Zipper Transcription Factors
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Fanconi Anemia Complementation Group Proteins

Share to Genomic Instability

Share to Replication Protein A

Share to S Phase

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 24351291
DOI: 10.1158/0008-5472.CAN-13-2474
PMCID: PMC5402619

Genes

BRCA1
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.PMID 24351291Read ↗

Lack of CAK complex accumulation at DNA damage sites in XP-B and XP-B/CS fibroblasts reveals differential regulation of CAK anchoring to core TFIIH by XPB and XPD helicases during nucleotide excision repair.Semantic proximity Read ↗

Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1.Semantic proximity Read ↗

Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights.Semantic proximity Read ↗

Nuclease delivery: versatile functions of SLX4/FANCP in genome maintenance.Semantic proximity Read ↗

Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair.Semantic proximity Read ↗

Generation of DNA single-strand displacement by compromised nucleotide excision repair.Semantic proximity Read ↗

NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites.Semantic proximity Read ↗

Nucleotide Excision Repair Is Associated with the Replisome and Its Efficiency Depends on a Direct Interaction between XPA and PCNASemantic proximity Read ↗

Dissection of the molecular defects caused by pathogenic mutations in the DNA repair factor XPC.Semantic proximity Read ↗

Functional and physical interaction between the mismatch repair and FA-BRCA pathwaysSemantic proximity Read ↗

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.Semantic proximity Read ↗

Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during StressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.