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Article

Elucidating emergence and transmission of multidrug-resistant tuberculosis in treatment experienced patients by whole genome sequencing.

PloS one - 1 Jan 2013

Clark Taane G, Mallard Kim, Coll Francesc, Preston Mark, Assefa Samuel, Harris David, Ogwang Sam, Mumbowa Francis, Kirenga Bruce, O'Sullivan Denise M, Okwera Alphonse, Eisenach Kathleen D, Joloba Moses, Bentley Stephen D, Ellner Jerrold J, Parkhill Julian, Jones-López Edward C, McNerney Ruth

Abstract excerpt

BACKGROUND: Understanding the emergence and spread of multidrug-resistant tuberculosis (MDR-TB) is crucial for its control. MDR-TB in previously treated patients is generally attributed to the selection of drug resistant mutants during inadequate therapy rather than transmission of a resistant strain. Traditional genotyping methods are not sufficient to distinguish strains in populations with a high burden of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mycobacterium tuberculosis

Share to Polymorphism, Genetic

Share to Sequence Analysis, DNA

Share to Tuberculosis, Multidrug-Resistant

Share to Tuberculosis Research and Epidemiology

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Identifiers

PMID: 24349420
DOI: 10.1371/journal.pone.0083012
PMCID: PMC3859632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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