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Article

Distribution of Bacterial α1,3-Galactosyltransferase Genes in the Human Gut Microbiome

13 Jan 2020

Abstract excerpt

Because of a loss-of-function mutation in the GGTA1 gene, humans are unable to synthetize α1,3-Galactose (Gal) decorated glycans and develop high levels of circulating anti-α1,3-Galactose antibodies (anti-Gal Abs). Anti-Gal Abs have been identified as a major obstacle of organ xenotransplantation responsible for hyperacute vascular rejection and delayed vascular insult, and play a role in several host-pathogen...

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PMID: 31998300
DOI: 10.3389/fimmu.2019.03000

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