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Article

Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota

23 Sept 2013

Abstract excerpt

We investigate how host mucus glycan composition interacts with dietary carbohydrate content to influence the composition and expressed functions of a human gut community. The humanized gnotobiotic mice mimic humans with a nonsecretor phenotype due to knockout of their α1-2 fucosyltransferase (Fut2) gene. The fecal microbiota of Fut2(-) mice that lack fucosylated host glycans show decreased alpha diversity...

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PMID: 24062455
DOI: 10.1073/pnas.1306070110

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