B-cell-specific ablation of β-1,4-galactosyltransferase 1 prevents aging-related IgG glycans changes and improves aging phenotype in mice.

doi:10.1016/j.jprot.2022.104717

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Article

B-cell-specific ablation of β-1,4-galactosyltransferase 1 prevents aging-related IgG glycans changes and improves aging phenotype in mice.

Journal of proteomics - 30 Sept 2022

Sha Jichen, Fan Jiteng, Zhang Rongrong, Gu Yong, Xu Xiaoyan, Ren Shifang, Gu Jianxin

Abstract excerpt

IgG N-glycans levels change with advancing age, making it a potential biomarker of aging. β-1,4-galactosyltransferase (B4GALT) gene expression levels also increase with aging. Ultra performance liquid chromatography (UPLC) was used to examine changes inserum IgG N-glycans at six time points during the aging process. Most serum IgG N-glycans changed with aging in WT but not in CD19-cre B4GALT1 floxed mice. The...

Topics

Aging
Animals
B-Lymphocytes
Immunoglobulin G
Mice
N-Acetyllactosamine Synthase
Neuraminic Acids
Phenotype
Polysaccharides

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Open in PubMed

Identifiers

PMID: 36084919
DOI: 10.1016/j.jprot.2022.104717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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