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Telomere and telomerase in stem cells

13 Mar 2007

Abstract excerpt

Telomeres, guanine-rich tandem DNA repeats of the chromosomal end, provide chromosomal stability, and cellular replication causes their loss. In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. In embryonic stem cells,...

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PMID: 17353922
DOI: 10.1038/sj.bjc.6603671

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