Telomere length regulation during cloning, embryogenesis and ageing

Abstract excerpt

Telomeres are nucleoprotein complexes at the end of eukaryotic chromosomes with an essential role in chromosome capping. Owing to the end-replication problem of DNA polymerase, telomeres shorten during each cell division. When telomeres become critically short, they loose their capping function, which in turn induces a DNA damage-like response. This mechanism inhibits cell proliferation at the senescence stage...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Animal Genetics and Reproduction
• Share to Telomeres, Telomerase, and Senescence
• Share to Tissue Engineering and Regenerative Medicine