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Telomere Length Reprogramming in Embryos and Stem Cells

1 Jan 2014

Abstract excerpt

Telomeres protect and cap linear chromosome ends, yet these genomic buffers erode over an organism's lifespan. Short telomeres have been associated with many age-related conditions in humans, and genetic mutations resulting in short telomeres in humans manifest as syndromes of precocious aging. In women, telomere length limits a fertilized egg's capacity to develop into a healthy embryo. Thus, telomere length...

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PMID: 24719895
DOI: 10.1155/2014/925121

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