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Article

Asparagine-linked glycosylation of bone morphogenetic protein-2 is required for secretion and osteoblast differentiation.

Glycobiology - 1 Mar 2014

Hang Qinglei, Zhou Ying, Hou Sicong, Zhang Dongmei, Yang Xiaojing, Chen Jianping, Ben Zhiyun, Cheng Chun, Shen Aiguo

Abstract excerpt

Bone morphogenetic protein-2 (BMP-2), a glycosylated protein, has been demonstrated to play a key role in osteoblast differentiation. However, the function of its glycosylation is incompletely understood. In this study, we examined the role that N-linked glycans (NLG) play in the secretion of BMP-2. Blocking the addition of NLGs or inhibiting initial glycan processing prevented the secretion of BMP-2. To identify...

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PMID: 24336949
DOI: 10.1093/glycob/cwt110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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