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Article

Identification and Functional Characterization of Glycosylation of Recombinant Human Platelet-Derived Growth Factor-BB in Pichia pastoris.

PloS one - 1 Jan 2015

Dai Mengmeng, Yu Changming, Fang Ting, Fu Ling, Wang Jing, Zhang Jun, Ren Jun, Xu Junjie, Zhang Xiaopeng, Chen Wei

Abstract excerpt

Yeast Pichia pastoris is a widely used system for heterologous protein expression. However, post-translational modifications, especially glycosylation, usually impede pharmaceutical application of recombinant proteins because of unexpected alterations in protein structure and function. The aim of this study was to identify glycosylation sites on recombinant human platelet-derived growth factor-BB (rhPDGF-BB)...

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Source

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Identifiers

PMID: 26701617
DOI: 10.1371/journal.pone.0145419
PMCID: PMC4689512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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