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Article

The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function.

The Journal of biological chemistry - 15 Dec 2006

Oganesian Anush, Au Sandra, Horst Jeremy A, Holzhausen Lars C, Macy Athena J, Pace James M, Bornstein Paul

Abstract excerpt

The function of the NH(2)-terminal propeptide of type I procollagen (N-propeptide) is poorly understood. We now show that a recombinant trimeric N-propeptide interacts with transforming growth factor-beta1 and BMP2 and exhibits functional effects in stably transfected cells. The synthesis of N-propeptide by COS-7 cells results in an increase in phosphorylation of Akt and Smad3 and is associated with a marked...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17018525
DOI: 10.1074/jbc.M607536200
PMCID: PMC3086210

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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