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Article

Glycosylation is a novel TGFβ1-independent post-translational modification of Smad2.

Biochemical and biophysical research communications - 22 Jan 2020

Gotoh Takaya, Iwahana Hiroyuki, Kannan Surya, Marei Reham Ghazal, Mousa Hanaa, Elgamal Mahmoud, Souchelnytskyi Serhiy

Abstract excerpt

Smad2 is a crucial component of intracellular signaling by transforming growth factor-β (TGFβ). Here we describe that Smad2 is glycosylated, which is a novel for Smad2 post-translational modification. We showed that the Smad2 glycosylation was inhibited upon treatment of cells with 17β-estradiol, and was enhanced in cells in a dense culture as compared to cells in a sparse culture. The Smad2 glycosylation was not...

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Identifiers

PMID: 31727370
DOI: 10.1016/j.bbrc.2019.11.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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