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Article

Effect of additional N-glycosylation signal in the N-terminal region on intracellular function of the human gonadotropin alpha-subunit.

Endocrine journal - 1 Jun 2003

Furuhashi Madoka, Suganuma Nobuhiko

Abstract excerpt

hCG, LH, FSH, and TSH are a family of heterodimeric glycoprotein hormones that contain a common alpha-subunit, but differ in their hormone-specific beta-subunits. The alpha-subunit has two N-glycosylation sites at Asn52 and Asn78. To obtain more information on the relationship between the structure and function of the alpha-subunit, we introduced a novel N-glycosylation site in the N-terminal region by mutating...

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Identifiers

PMID: 12940452
DOI: 10.1507/endocrj.50.245

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