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Article

Biological role of site-specific O-glycosylation in cell adhesion activity and phosphorylation of osteopontin.

The Biochemical journal - 9 May 2018

Oyama Midori, Kariya Yoshinobu, Kariya Yukiko, Matsumoto Kana, Kanno Mayumi, Yamaguchi Yoshiki, Hashimoto Yasuhiro

Abstract excerpt

Osteopontin (OPN) is an extracellular glycosylated phosphoprotein that promotes cell adhesion by interacting with several integrin receptors. We previously reported that an OPN mutant lacking five O-glycosylation sites (Thr134/Thr138/Thr143/Thr147/Thr152) in the threonine/proline-rich region increased cell adhesion activity and phosphorylation compared with the wild type. However, the role of O-glycosylation in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29626154
DOI: 10.1042/BCJ20170205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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