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An update on Clostridioides difficile population structure and genomics.

Clinical microbiology reviews - 11 Jun 2026

Beebe Merilyn A, Sorg Joseph A

Abstract excerpt

SUMMARYSince its first isolation in 1935, several thousand Clostridioides difficile isolates have been collected and analyzed. These isolates belong to a diverse phylogeny consisting of five main clades and at least three cryptic clades. While clade 1 represents the largest and most diverse of the clades, clades 2 and 5 are the best studied, consisting of several strains attributed to the most severe clinical...

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Identifiers

PMID: 41914740
DOI: 10.1128/cmr.00296-25
PMCID: PMC13255554

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