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Article

Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair.

Nature biotechnology - 1 Jan 2014

Polak Paz, Lawrence Michael S, Haugen Eric, Stoletzki Nina, Stojanov Petar, Thurman Robert E, Garraway Levi A, Mirkin Sergei, Getz Gad, Stamatoyannopoulos John A, Sunyaev Shamil R

Abstract excerpt

Carcinogenesis and neoplastic progression are mediated by the accumulation of somatic mutations. Here we report that the local density of somatic mutations in cancer genomes is highly reduced specifically in accessible regulatory DNA defined by DNase I hypersensitive sites. This reduction is independent of any known factors influencing somatic mutation density and is observed in diverse cancer types, suggesting a...

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Share to Carcinogenesis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Share to Regulatory Sequences, Nucleic Acid

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Identifiers

PMID: 24336318
DOI: 10.1038/nbt.2778
PMCID: PMC4116484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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