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Methylation Profiling of Archived Non–Small Cell Lung Cancer: A Promising Prognostic System

15 Jun 2005

Abstract excerpt

PURPOSE: Enhanced prognostication power is becoming more desirable in clinical oncology. In this study, we explored the prognostic potential of multigene hypermethylation profiling in non-small-cell lung cancer. EXPERIMENTAL DESIGN: We evaluated a panel of eight genes (p16, APC, ATM, hMLH1, MGMT, DAPK, ECAD, and RASSF1A) using methylation-specific PCR in 105 archived specimens of non-small-cell lung cancer...

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PMID: 15958624
DOI: 10.1158/1078-0432.ccr-04-2378

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