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Epigenetic therapy in non-small-cell lung cancer: targeting DNA methyltransferases and histone deacetylases

17 Jul 2013

Abstract excerpt

INTRODUCTION: Epigenetics refers to heritable modifications of DNA and associated chromatin components that influence gene expression without altering DNA coding sequence. Epigenetic dysregulation is a central contributor to oncogenesis and is increasingly a focus of interest in cancer therapeutic research. Two key levels of aberrant epigenetic control are DNA methylation and histone acetylation. Primary...

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PMID: 23859704
DOI: 10.1517/14712598.2013.819337

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