Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic Therapy of Non-Small Cell Lung Cancer Using Decitabine (5-Aza-2′-Deoxycytidine)

1 Jan 2013

Abstract excerpt

Epigenetic analysis shows that many genes that suppress malignancy are silenced by aberrant DNA methylation in lung cancer. Many of these genes are interesting targets for reactivation by the inhibitor of DNA methylation, decitabine (5-aza-2'-deoxycytidine, DAC). A pilot study on intense dose DAC showed promising results in patients with metastatic non-small cell lung cancer (NSCLC). However, subsequent clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research
Share to Lung Cancer Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23908969
DOI: 10.3389/fonc.2013.00188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic Therapy of Non-Small Cell Lung Cancer Using Decitabine (5-Aza-2′-Deoxycytidine)PMID 23908969Read ↗

Epigenetic therapy of cancer with 5-aza-2'-deoxycytidine (decitabine).Semantic proximity Read ↗

Epigenetic therapy in non-small-cell lung cancer: targeting DNA methyltransferases and histone deacetylasesSemantic proximity Read ↗

Aberrant epigenetic regulation: a central contributor to lung carcinogenesis and a new therapeutic target.Semantic proximity Read ↗

Azacitidine and decitabine have different mechanisms of action in non-small cell lung cancer cell linesSemantic proximity Read ↗

Will Dna Methylation Inhibitors Work In Solid Tumors? A Review Of The Clinical Experience With Azacitidine And Decitabine In Solid TumorsSemantic proximity Read ↗

Dissection of demethylation and toxicity induced gene expression changes after decitabine treatmentSemantic proximity Read ↗

Novel prodrugs of decitabine with greater metabolic stability and less toxicitySemantic proximity Read ↗

Evolution of decitabine developmentSemantic proximity Read ↗

DecitabineSemantic proximity Read ↗

Targeted inhibition of genome-wide DNA methylation analysis in epigenetically modulated phenotypes in lung cancer.Semantic proximity Read ↗

Epigenetic anti-cancer treatment with a stabilized carbocyclic Decitabine analogueSemantic proximity Read ↗

Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.