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Article

Phenotypic pliancy and the breakdown of epigenetic polycomb mechanisms.

PLoS computational biology - 1 Feb 2023

Lambros Maryl, Sella Yehonatan, Bergman Aviv

Abstract excerpt

Epigenetic regulatory mechanisms allow multicellular organisms to develop distinct specialized cell identities despite having the same total genome. Cell-fate choices are based on gene expression programs and environmental cues that cells experience during embryonic development, and are usually maintained throughout the life of the organism despite new environmental cues. The evolutionarily conserved Polycomb...

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PMID: 36809239
DOI: 10.1371/journal.pcbi.1010889
PMCID: PMC9983867

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