Article
Many inflammatory bowel disease risk loci include regions that regulate gene expression in immune cells and the intestinal epithelium.
Gastroenterology - 1 Apr 2014
Mokry Michal, Middendorp Sabine, Wiegerinck Caroline L, Witte Merlijn, Teunissen Hans, Meddens Claartje A, Cuppen Edwin, Clevers Hans, Nieuwenhuis Edward E S
Abstract excerpt
BACKGROUND & AIMS: The contribution of genetic factors to the pathogenesis of inflammatory bowel disease (IBD) has been established by twin, targeted-sequencing, and genome-wide association studies. These studies identified many risk loci, and research is underway to identify causal variants. The...
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