Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A critical role of the PTEN/PDGF signaling network for the regulation of radiosensitivity in adenocarcinoma of the prostate.

International journal of radiation oncology, biology, physics - 1 Jan 2014

Christensen Michael, Najy Abdo J, Snyder Michael, Movilla Lisa S, Kim Hyeong-Reh Choi

Abstract excerpt

PURPOSE: Loss or mutation of the phosphate and tensin homologue (PTEN) is a common genetic abnormality in prostate cancer (PCa) and induces platelet-derived growth factor D (PDGF D) signaling. We examined the role of the PTEN/PDGF axis on radioresponse using a murine PTEN null prostate epithelial cell model. METHODS AND MATERIALS: PTEN wild-type (PTEN+/+) and PTEN knockout (PTEN-/-) murine prostate epithelial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lymphokines
Share to Mice, Nude

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, SCID

Share to Neoplasm Invasiveness

Share to Platelet-Derived Growth Factor

Share to PTEN Phosphohydrolase

Share to Radiation Tolerance

Share to Receptor, Platelet-Derived Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 24331662
DOI: 10.1016/j.ijrobp.2013.10.019
PMCID: PMC4920083

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A critical role of the PTEN/PDGF signaling network for the regulation of radiosensitivity in adenocarcinoma of the prostate.PMID 24331662Read ↗

PTEN Regulates PDGF Ligand Switch for β-PDGFR Signaling in Prostate CancerSemantic proximity Read ↗

The PTEN Conundrum: How to Target PTEN-Deficient Prostate CancerSemantic proximity Read ↗

rAAV-Delivered PTEN Therapeutics for Prostate CancerSemantic proximity Read ↗

Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancerSemantic proximity Read ↗

Targeting CXCR1 and CXCR2 to overcome radiotherapy resistance in PTEN-deficient prostate carcinomaSemantic proximity Read ↗

Pten dose dictates cancer progression in the prostate.Semantic proximity Read ↗

PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity.Semantic proximity Read ↗

Differential impact of PI3K/AKT/mTOR signaling on tumor initiation and progression in animal models of prostate cancer.Semantic proximity Read ↗

Dissecting the role of microRNAs in the radiation response of human prostate cancerSemantic proximity Read ↗

<i>Pten</i> Deficiency Activates Distinct Downstream Signaling Pathways in a Tissue-Specific MannerSemantic proximity Read ↗

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.Semantic proximity Read ↗

TGFβ signaling limits lineage plasticity in prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.