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Article

PTEN Regulates PDGF Ligand Switch for β-PDGFR Signaling in Prostate Cancer

28 Dec 2011

Abstract excerpt

Platelet-derived growth factor (PDGF) family members are potent growth factors that regulate cell proliferation, migration, and transformation. Clinical studies have shown that both PDGF receptor β (β-PDGFR) and its ligand PDGF D are up-regulated in primary prostate cancers and bone metastases, whereas PDGF B, a classic ligand for β-PDGFR, is not frequently detected in clinical samples. In this study, we examined...

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PMID: 22209699
DOI: 10.1016/j.ajpath.2011.11.021

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