Article

Targeting CXCR1 and CXCR2 to overcome radiotherapy resistance in PTEN-deficient prostate carcinoma

2020-03-16

Abstract excerpt

<h4> ABSTRACT </h4> Functional impairment of the tumour-suppressor PTEN is common in primary-prostate cancer and has been linked to relapse post-radiotherapy (RT). Pre-clinical modelling supports elevated CXC-chemokine signaling as a critical mediator of PTEN -depleted disease progression and therapeutic resistance. We assessed the correlation of PTEN -deficiency with CXC-chemokine signaling and its associati...

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Literature Corpus work: 5eff399d-1fd1-5001-ac0b-7d2d7df9c562
DOI: 10.1101/2020.03.16.993394

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