Article
Sustained cytokine production and immunophenotypic changes in human neuroblastoma cell lines transduced with a human gamma interferon vector.
Cancer gene therapy - 1 Sept 1995
Uçar K, Seeger R C, Challita P M, Watanabe C T, Yen T L, Morgan J P, Amado R, Chou E, McCallister T, Barber J R
Abstract excerpt
The majority of human neuroblastomas express low to undetectable levels of major histocompatibility complex (MHC) class I and II antigens (MHC-I and -II). We studied the effects of gamma interferon (gamma-IFN) transduction on expression of these antigens in six human neuroblastoma cell lines with...
Topics
- B7-1 Antigen
- CD28 Antigens
- CD57 Antigens
- Genetic Vectors
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Humans
- Immunophenotyping
- Intercellular Adhesion Molecule-1
- Interferon-gamma
- Neuroblastoma
- Phenotype
- Radiation Tolerance