Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE-knockout mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2014

Zurkinden Line, Solcà Curzio, Vögeli Isabelle A, Vogt Bruno, Ackermann Daniel, Erickson Sandra K, Frey Felix J, Sviridov Dmitri, Escher Geneviève

Abstract excerpt

In humans, sterol 27-hydroxylase (CYP27A1) deficiency leads to cholesterol deposition in tendons and vasculature. Thus, in addition to its role in bile acid synthesis, where it converts cholesterol to 27-hydroxycholesterol (27-OHC), CYP27A1 may also be atheroprotective. Cyp27A1-deficient (Cyp27A1(-/-)) mice were crossed with apolipoprotein E (apoE)-deficient mice. Cyp27A1(+/+)/apoE(-/-) [ApoE-knockout (KO)],...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins E
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Fluids

Share to Cholestanetriol 26-Monooxygenase

Share to Gene Dosage

Share to Genotype

Share to Mice, Knockout

Source

Open in PubMed Open full text

Identifiers

PMID: 24327605
DOI: 10.1096/fj.13-233791
PMCID: PMC4046167

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE-knockout mice.PMID 24327605Read ↗

Role of CYP27A in cholesterol and bile acid metabolism.Semantic proximity Read ↗

Human Sterol 27-Hydroxylase (CYP27) Overexpressor Transgenic Mouse ModelSemantic proximity Read ↗

CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development.Semantic proximity Read ↗

On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1−/− miceSemantic proximity Read ↗

Maternal sterol 27-hydroxylase is crucial for securing fetal developmentSemantic proximity Read ↗

The growth suppressor p27 <sup>Kip1</sup> protects against diet‐induced atherosclerosisSemantic proximity Read ↗

Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.Semantic proximity Read ↗

ApoE knockout rabbits: A novel model for the study of human hyperlipidemia.Semantic proximity Read ↗

Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism.Semantic proximity Read ↗

Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient miceSemantic proximity Read ↗

The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.Semantic proximity Read ↗

Biologic role(s) of the 25(R),26-hydroxycholesterol metabolic pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.