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Article

CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development.

Scientific reports - 29 May 2020

Aherrahrou Redouane, Kulle Alexandra E, Alenina Natalia, Werner Ralf, Vens-Cappell Simeon, Bader Michael, Schunkert Heribert, Erdmann Jeanette, Aherrahrou Zouhair

Abstract excerpt

CYP17A1 is a cytochrome P450 enzyme with 17-alpha-hydroxylase and C17,20-lyase activities. CYP17A1 genetic variants are associated with coronary artery disease, myocardial infarction and visceral and subcutaneous fat distribution; however, the underlying pathological mechanisms remain unknown. We aimed to investigate the function of CYP17A1 and its impact on atherosclerosis in mice. At 4-6 months,...

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Identifiers

PMID: 32472014
DOI: 10.1038/s41598-020-65601-0
PMCID: PMC7260244

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