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Article

Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism.

Atherosclerosis - 1 Feb 2011

Karuna Ratna, Holleboom Adriaan G, Motazacker Mohammad M, Kuivenhoven Jan Albert, Frikke-Schmidt Ruth, Tybjaerg-Hansen Anne, Georgopoulos Spiros, van Eck Miranda, van Berkel Theo J C, von Eckardstein Arnold, Rentsch Katharina M

Abstract excerpt

Secretion of 27-hydroxycholesterol (27OHC) from macrophages is considered as an alternative to HDL-mediated reverse transport of excess cholesterol. We investigated 27OHC-concentrations in plasma of humans and mice with monogenic disorders of HDL metabolism. As compared to family controls mutations in the genes for apolipoprotein A-I, ATP binding cassette transporter (ABC) A1 and lecithin:cholesterol...

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Share to Apolipoprotein A-I
Share to ATP Binding Cassette Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily G, Member 1

Share to Cholesterol Ester Transfer Proteins

Share to Hydroxycholesterols

Share to Lipid Metabolism, Inborn Errors

Share to Phosphatidylcholine-Sterol O-Acyltransferase

Share to Scavenger Receptors, Class B

Source

Identifiers

PMID: 21130455
DOI: 10.1016/j.atherosclerosis.2010.10.042

Genes

LCAT
CETP
ABCA1
ABCG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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