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Article

Role of CYP27A in cholesterol and bile acid metabolism.

Journal of lipid research - 1 Jan 2005

Dubrac Sandrine, Lear Steven R, Ananthanarayanan Meena, Balasubramaniyan Natarajan, Bollineni Jaya, Shefer Sarah, Hyogo Hideyuki, Cohen David E, Blanche Patricia J, Krauss Ronald M, Batta Ashok K, Salen Gerald, Suchy Frederick J, Maeda Nobuyo, Erickson Sandra K

Abstract excerpt

The CYP27A gene encodes a mitochondrial cytochrome P450 enzyme, sterol 27-hydroxylase, that is expressed in many different tissues and plays an important role in cholesterol and bile acid metabolism. In humans, CYP27A deficiency leads to cerebrotendinous xanthomatosis. To gain insight into the roles of CYP27A in the regulation of cholesterol and bile acid metabolism, cyp27A gene knockout heterozygous, homozygous,...

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PMID: 15520450
DOI: 10.1194/jlr.M400219-JLR200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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