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Article

Association of genetically determined plasma hepatocyte growth factor with lung cancer and its subtypes: Mendelian randomization and mediation analysis.

Medicine - 3 Apr 2026

Xu Feiqi, Xu Qingyun, Yu Jiamian, Le Yanna, Fu Hong, Ruan Xiaoying, Shi Yanpeng, Zhu Lin, Chai Jianrong, Zhou Yu, Ding Lan, Shi Yanyan

Abstract excerpt

Growing scientific evidence suggested that hepatocyte growth factor (HGF) might play a crucial role in the development of lung cancer, which might be influenced by the epidermal growth factor (EGF)/EGF receptor. However, the specific causality behind the association has not been clarified due to potential bias. Thus, a Mendelian randomization (MR) study was conducted to investigate the effects of gene-determined...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41931347
DOI: 10.1097/MD.0000000000048178
PMCID: PMC13052923

Genes

HGF
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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