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Article

A testing framework for identifying susceptibility genes in the presence of epistasis.

American journal of human genetics - 1 Jan 2006

Millstein Joshua, Conti David V, Gilliland Frank D, Gauderman W James

Abstract excerpt

An efficient testing strategy called the "focused interaction testing framework" (FITF) was developed to identify susceptibility genes involved in epistatic interactions for case-control studies of candidate genes. In the FITF approach, likelihood-ratio tests are performed in stages that increase in the order of interaction considered. Joint tests of main effects and interactions are performed conditional on...

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Identifiers

PMID: 16385446
DOI: 10.1086/498850
PMCID: PMC1380213

Genes

CAT
MPO
NQO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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