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Article

Genome-wide two-locus epistasis scans in prostate cancer using two European populations.

Human genetics - 1 Jul 2012

Tao Sha, Feng Junjie, Webster Timothy, Jin Guangfu, Hsu Fang-Chi, Chen Shyh-Huei, Kim Seong-Tae, Wang Zhong, Zhang Zheng, Zheng Siqun L, Isaacs William B, Xu Jianfeng, Sun Jielin

Abstract excerpt

Approximately 40 single nucleotide polymorphisms (SNPs) that are associated with prostate cancer (PCa) risk have been identified through genome-wide association studies (GWAS). However, these GWAS-identified PCa risk-associated SNPs can explain only a small proportion of heritability (~13%) of PCa risk. Gene-gene interaction is speculated to be one of the major factors contributing to the so-called missing...

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Share to Epistasis, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 22367438
DOI: 10.1007/s00439-012-1148-4
PMCID: PMC3634576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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