Article
Whole genome sequencing reveals complex evolution patterns of multidrug-resistant Mycobacterium tuberculosis Beijing strains in patients.
PloS one - 1 Jan 2013
Merker Matthias, Kohl Thomas A, Roetzer Andreas, Truebe Leona, Richter Elvira, Rüsch-Gerdes Sabine, Fattorini Lanfranco, Oggioni Marco R, Cox Helen, Varaine Francis, Niemann Stefan
Abstract excerpt
Multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains represent a major threat for tuberculosis (TB) control. Treatment of MDR-TB patients is long and less effective, resulting in a significant number of treatment failures. The development of further resistances leads to extensively drug-resistant (XDR) variants. However, data on the individual reasons for treatment failure, e.g. an induced...
Topics
- Antitubercular Agents
- Drug Resistance, Multiple, Bacterial
- Evolution, Molecular
- Genome, Bacterial
- Genotype
- Humans
- Mutation
- Mycobacterium tuberculosis
- Polymorphism, Single Nucleotide