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Article

Endothelial insulin-like growth factor-1 modulates proliferation and phenotype of smooth muscle cells induced by low shear stress.

Annals of biomedical engineering - 1 Apr 2014

Wang Lu, Han Yue, Shen Yan, Yan Zhi-Qiang, Zhang Ping, Yao Qing-Ping, Shen Bao-Rong, Gao Li-Zhi, Qi Ying-Xin, Jiang Zong-Lai

Abstract excerpt

Endothelial cells (ECs) are directly exposed to shear stress and modulate the neighboring vascular smooth muscle cells (VSMCs), which plays important roles in vascular remodeling during atherosclerosis. Our previous research revealed that insulin-like growth factors (IGFs) might participate in low shear stress (LowSS) induced vascular remodeling, which remains to be elucidated. Using EC/VSMC co-cultured...

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Identifiers

PMID: 24322591
DOI: 10.1007/s10439-013-0957-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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