Article
The N-terminal strand modulates immunoglobulin light chain fibrillogenesis.
Biochemical and biophysical research communications - 10 Jan 2014
del Pozo-Yauner Luis, Wall Jonathan S, González Andrade Martín, Sánchez-López Rosana, Rodríguez-Ambriz Sandra L, Pérez Carreón Julio I, Ochoa-Leyva Adrián, Fernández-Velasco D Alejandro
Abstract excerpt
It has been suggested that the N-terminal strand of the light chain variable domain (V(L)) protects the molecule from aggregation by hindering spurious intermolecular contacts. We evaluated the impact of mutations in the N-terminal strand on the thermodynamic stability and kinetic of fibrillogenesis of the V(L) protein 6aJL2. Mutations in this strand destabilized the protein in a position-dependent manner,...
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